Unspoken words for thought

Posts tagged ‘biology’

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PUMA, BBC3….

PUMA, BBC3.

The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3)…

Well, you learn sth new everyday.. 

Green Eyes In Beautiful Detail

Wrote a poem about green eyes before, here are two videos I made lately:

Did you think the eyes are smooth spheres? Macro view of this eye reveals a pattern that reminds me of craters.. Maybe on Alien territories 😛

What do the patterns of this iris remind you of? How about Mediterranean sea, or a bizarre suggestion by a friend- Petri dish or sperms surrounding an egg.

Ok, some descriptions don’t sound pretty… Nevertheless, how intricate are the designs of out eyes? Evolution has created endless forms most beautiful! Spare a moment to be grateful for our sight and these beautiful & well designed features…

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The iris is a contractile structure, consisting mainly of smooth muscle, surrounding the pupil. Light enters the eye through the pupil, and the iris regulates the amount of light by controlling the size of the pupil. The iris contains two groups of smooth muscles; a circular group called the sphincter pupillae, and a radial group called the dilator pupillae. When the sphincter pupillae contract, the iris decreases or constricts the size of the pupil. The dilator pupillae, innervated by sympathetic nerves from the superior cervical ganglion, cause the pupil to dilate when they contract. These muscles are sometimes referred to as intrinsic eye muscles. The sensory pathway (rod or cone, bipolar, ganglion) is linked with its counterpart in the other eye by a partial crossover of each eye’s fibers. This causes the effect in one eye to carry over to the other.

(Wikipedia)

Nature will bear the closest inspection. She invites us to lay our eye level with her smallest leaf, and take an insect view of its plain.

–Henry David Thoreau 

“The soul, fortunately, has an interpreter – often an unconscious but still a faithful interpreter – in the eye.” 

— Charlotte Brontë, Jane Eyre

About weak points [of the Origin] I agree. The eye to this day gives me a cold shudder, but when I think of the fine known gradations, my reason tells me I ought to conquer the cold shudder.

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Ovoviviparity….

Ovoviviparity.

Word of the day.

Pupil Constriction and Dilation

So the other week I bought some lens extensions for taking macro images as one of my hobbies is to take pictures of nature. I thought I’d give filming in HD ago and chose the eye as my subject because of it’s intricately beautiful design.

As you can see the video reveals details of the iris and pupil including their movements- constriction and dilation in this case. This didn’t happen to a friend’s eye that I initially filmed. I’m puzzled by this…

After some research and looking at other videos that people posted I came across things such as autonomic nervous system, galvanic response, adrenaline levels… Maybe the pupil is changing in size due to the blood circulation? However someone suggested it could just be the lights. Although additionally, I should point out that I am affected by myopia- essentially shortsightedness which might affect the constriction/dilation as well?

I’m still not sure what exactly causes this relatively fast paced change in size in the pupil & is wondering if many people have eyes that behave like this….

Motivation for future scientist wanna-bes

Awesomeness.

Arnold Young, (aka the Ph.Diddy) is a biotech Ph.D candidate. Arnold was an A+ student, and is now ready to take over the world of science! He soon discovers how life in the lab is filled with drive and devotion, frustrations and fulfillment, hard work, late hours, repeated experiments, peer review and a strive for respect and recognition. How will the ups and downs of life in the lab shape our Ph.Diddy on his journey to have his first scientific paper published?

Acknowledgements: This video is inspired by all the dedicated everyday-heroes-of-science. Invitrogen recognizes your passion and admires your perseverance!

Check us out on Facebook at http://www.facebook.com/invitrogen

http://transcript

I was the black belt of my class, marked out as an achiever. First day on the job, enter the gene-weaver.
My future colleagues look up from the PCR machine, checking me out man. The Ph.Diddy’s on the scene.
So I claim my pipette and pimp it up to halt the theivin’. Get the thermocycler going, my samples cool chilling.
Yeah, I shoot my tips like I’ve been here all my life. Wait for instrument time with my free pizza slice.
I run my first Western blot. Man, this lab scene is easy. But wait up, hold a minute. I’m feeling kinda queasy.
Is that Trizol I can smell? Oh, my head’s in a spin! ‘ve gone and dropped my freakin’ sample in the biohaz bin.

He’s a super fly grad. Life plans to shape the future, that’s right!
Sees his name in lights and a centre spread in Nature. All right!

I’m always splitting cells, always working late. I’ve cleared the biohazard bin so much I herniate.
Got samples botched, samples lost, samples dropped on the floor. Messy benches, empty buffers, lab politics galore.
My PI’s buggin’. Man he sounds like my father. Western blot once again, but development shows nada.
I’m doin’ my time in the cell culture hood – at the weekend bro. It’s the only time I could!
Then suddenly my data is starting to make sense. Even Western blot bands start to make an appearance.
So I repeat once again all the steps I need to follow. But every culture well… turned yellow.

He’s a super fly grad. Life plans to shape the future, that’s right!
Sees his name in lights and a centre spread in Nature. All right!
I’m talkin’ ’bout the ooh, ooh…

Serum and media get swiped with no apology. And all my cells are showing abnormal morphology.
So now my PI’s freaking, “Find something you can prove!” But contamination aggravation knocks me off my groove.
So I stay late once again as the lab detainee. Yeah, its 9 pm but the thermocycler’s free
I don’t understand! What’s happened now? That’s it. Yeah, time to give up. I’m throwing in the towel.

Ooh, ooh, supergrad. I’m talkin’ ’bout the ooh, ooh… Super bad lab grad, yeah!
Ooh, ooh, supergrad. I’m talkin’ ’bout the ooh, ooh… Super bad lab grad, yeah!

My transfection worked – confirmed with Pol II chIP – mutagenesis determined the TF targeted.
I’m not going down! I can still do BioChem! My genes will express, I’m gonna beat it out of them.
And yeah, I must have results that no one can undress. And quickly move my paper from in prep to in press.
I’m finally finished writing the discussion, whilst my PI once again, “tweaks” my introduction.
So, here we go, yo. Here’s the scenario: Peer review’s due to hit. When exactly? I don’t know.
My paper will be published. My research is legit. OK it’s not quite Nature but, I think I nailed it!

He’s a super fly grad. Life plans to shape the future, that’s right!
Sees his name in lights and a centre spread in Nature. All right!
He’s a super fly grad. Life plans to shape the future, that’s right!
Sees his name in lights and a centre spread in Nature. All right!
Ooh, ooh, supergrad. I’m talkin’ ’bout the ooh, ooh… Super bad lab grad, yeah!

Bio-mimicry

I have always been awe struck at the physical world around us, which has been in my opinion one way or another extremely influenced by nature and biology… More so than our imagination. Nature of order and patterns have been explored by the incurably curious, therefore science has evolved to improve our everyday lives by exploring complexities in biology and biochemistry.

Perhaps as a biologist, I am biased on this topic of ‘creationism’ in saying that we are inspired more so by what is around us than what we can create. However, even if pure creations of the human mind can be extraordinary, nature has by the process of the astounding force of evolution, been perfecting its designs. Thinking about it, apart from living form on Earth, what other existences are able to self-improve in the same way? Do physical laws change or better themselves? Do rocks gradually become more beneficial in one way or another and are chemicals changing to benefit the rest of creation?

Here is an article from the BBC which encompasses difference bio-mimicry for us to ponder over:

http://www.bbc.co.uk/news/business-15480620

Conclusion: Biology is awesome.

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